The young workers - from Canada, Australia, Argentina and the UK - will meet with members of the General Union of Transport Workers (GUTW) in Palestine.
As part of the three-day mission they will visit the ITF Palestinian truck drivers’ project that has improved border crossing facilities, join truck drivers during a day's work and talk to workers about what other support they need.
ITF youth co-ordinator Baker Khundakji said: "The ITF young transport workers have stood in solidarity with workers under difficult circumstances and struggles in different parts of the world. This is more than just a visit; this is the next step in the practical support for transport workers in Palestine.
“We want to know what more we can do to support the Palestinian workers to improve their working conditions, and the young workers on this mission will take this forward."
You can follow the mission on social media by searching for #ITFyouth and via the Facebook group and Twitter account.